Alembic Pharmaceuticals Hiring for Drug Discovery at Vadodara

Alembic Pharmaceuticals Jobs | Biochemist / Chemical Biologist – Drug Discovery Vacancy

Alembic Pharmaceuticals Ltd. is inviting applications for the position of Biochemist / Chemical Biologist – Drug Discovery at its Vadodara, Gujarat location. The company is looking for a hands-on scientist with expertise in biochemical and biophysical assays, SPR, FRET-based assays and mammalian cell culture. This full-time, on-site opportunity offers exposure to drug discovery programs across multiple therapeutic areas and collaboration with global scientific partners.

Alembic Pharmaceuticals Hiring for Below Position

1. Department: Drug Discovery

Location: Vadodara, India | Full-time On-site

Reports to: Head of Drug Discovery

About the Role:

Alembic is hiring a hands-on Biochemist with expertise in biochemical and biophysical assays, SPR, FRET-based assays, and mammalian cell culture to support drug discovery across therapeutic areas, including inflammation, immunology, oncology, metabolic disorders, and other disease areas. The scientist will independently develop assays, characterize compound-target interactions, and generate data supporting hit identification, hit-to-lead, and lead optimization.

We are looking for a proactive, highly collaborative go-getter who thrives in fast-paced discovery environments. This role offers a unique opportunity to contribute to discovery programs in India while actively bridging into the U.S. biotech ecosystem, collaborating with global scientific partners to help deliver transformational medicines. In this position, you will not only make a meaningful scientific contribution but also grow as a drug discovery scientist, gaining broad exposure to multidisciplinary research and direct involvement in advancing innovative therapeutic ideas.

Key Responsibilities

• Develop, optimize, and validate biochemical assays to measure enzyme activity, compound binding, and protein-protein interactions across disease-relevant targets.
• Perform surface plasmon resonance (SPR) experiments to determine binding affinity and characterize association and dissociation kinetics.
• Design and execute FRET and TR-FRET, BLI assays, including HTRF formats, with appropriate controls to identify assay interference.
• Develop and execute complementary biophysical assays for hit confirmation and compound characterization using techniques such as fluorescence polarization (FP), Isothermal titration calorimetry (ITC), Alpha Screen, AlphaLISA, Thermal shift assay (TSA), DSC, Microscale Thermophoresis (MST), ELISA, and circular dichroism (CD).
• Express, purify, and characterize recombinant proteins for biochemical and biophysical studies.
• High-throughput screening (HTS) of small-molecule libraries, dose-response studies, hit confirmation, counter-screening, and selectivity profiling.
• Independently maintain mammalian or insect cell cultures, including aseptic handling, passaging, cryopreservation, recovery and routine contamination checks.
• Develop and perform disease-relevant cell-based assays to assess compound potency, viability, functional activity, and cellular target engagement.
• Develop and run NanoBRET target engagement assays in live cells to confirm intracellular binding and selectivity.
• Troubleshoot assays, assess reproducibility, signal quality, and suitability for screening Collaborate with medicinal chemistry, DMPK and pharmacology teams to guide
• compound progression.
• Maintain laboratory records, prepare SOPs and technical reports, and present results

How To Apply:

Interested candidates can send their updated resume to drugdiscoverycareer@alembic.co.in.

Who Can Apply?

Candidates with experience in biochemical and biophysical assays.

Professionals with expertise in SPR and FRET-based assays.

Candidates experienced in mammalian or insect cell culture.

Professionals with knowledge of recombinant protein expression, purification and characterization.

Candidates with experience in high-throughput screening and compound characterization.

Scientists with relevant experience in drug discovery research and cell-based assays.

Career Growth at Alembic Pharmaceuticals

Alembic Pharmaceuticals offers opportunities to work in pharmaceutical research and drug discovery. This position provides exposure to multidisciplinary research across therapeutic areas, including inflammation, immunology, oncology and metabolic disorders.

The role offers opportunities to collaborate with medicinal chemistry, DMPK and pharmacology teams, as well as global scientific partners. Professionals can strengthen their expertise in biochemical and biophysical assays and contribute to drug discovery programs. Career progression depends on individual performance, scientific expertise and organizational requirements.

Frequently Asked Questions

1. Which position is available at Alembic Pharmaceuticals?

Alembic Pharmaceuticals is hiring for the position of Biochemist / Chemical Biologist – Drug Discovery.

2. What is the required experience for Alembic Pharmaceuticals jobs?

The specific experience requirement is not mentioned in the provided job details.

3. What technical skills are required for this position?

Candidates should have expertise in biochemical and biophysical assays, SPR, FRET-based assays and mammalian cell culture.

4. Where is the job location for Alembic Pharmaceuticals vacancies?

The job location is Vadodara, Gujarat, India.

5. How can candidates apply for Alembic Pharmaceuticals jobs?

Interested candidates can send their updated resume to drugdiscoverycareer@alembic.co.in.

Alembic Pharmaceuticals hiring Biochemist / Chemical Biologist for Drug Discovery at Vadodara, Gujarat.